The Chinese medicine Sinisan shown to effectively address symptoms of nonalcoholic fatty liver disease

Sinisan, a traditional Chinese medicine, has been shown to improve symptoms of nonalcoholic fatty liver disease (NAFLD). The study, which was published in the journal BMC Complementary and Alternative Medicine, provided scientific evidence on the effect of Sinisan on NAFLD in mice.

  • Researchers from Beijing University of Chinese Medicine in China exposed mice to chronic stress.
  • Then, they administered Sinisan to mice with stress-induced NALFD for nine weeks.
  • Sinisan is comprised of four herbal medicines: Aurantii Immaturus Fructus (Zhi-Shi), Paeonae Alba Radix (Bai-Shao), Licorice Root (Gan-Cao), and Bupleuri Radix (Chai-Hu) with a dose proportion of 1:1:1:1.
  • The induction of long-term stress resulted in steatosis and nonalcoholic steatohepatitis (NASH).
  • The body weight of the mice also decreased.
  • Furthermore, exposure to chronic stress resulted in oxidative stress and chronic inflammation in the liver.
  • The Sinisan treatment improved stress symptoms in mice, such as increased body weight and sucrose preference.
  • It also improved hepatic steatosis and reduced the aspartate aminotransferase and alanine aminotransferase levels.
  • In addition, the Sinisan treatment significantly decreased total cholesterol, triglycerides, and free fatty acids in the liver of mice.
  • Moreover, the treatment also reduced the level of liver interleukin-6, suggesting that the beneficial effect of Sinisan on NAFLD may be partly due to the anti-inflammatory effect.

In conclusion, the beneficial effect of the traditional Chinese medicine Sinisan involves stress reduction, anti-steatosis, and anti-inflammation.

Read the full text of the study at this link.

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Journal Reference:

Cheng F, Ma C, Wang X, Zhai C, Wang G, Xu X, Mu J, Li C, Wang Z, Zhang X, …Wang Q. EFFECT OF TRADITIONAL CHINESE MEDICINE FORMULA SINISAN ON CHRONIC RESTRAINT STRESS-INDUCED NONALCOHOLIC FATTY LIVER DISEASE: A RAT STUDY. BMC Complementary and Alternative Medicine. 7 April 2017; 17(203). DOI: 10.1186/s12906-017-1707-2

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